Malignt melanom kan opstå hvor der findes melanocytter - i hud i slimhinder som mundhule næsekavitet bihuler tarmslimhinde og ydre genitalslimhinde i øjne og i lymfeknuder. I 8-10 af tilfældene er primærtumors lokalisation ukendt og diagnosen stilles på grund af metastaser.
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